The Star of Life was created following complaints from the American Red Cross that the common use of an Omaha orange cross against a reflective white background was an imitation of their clearly recognized symbol. Investigating these concerns and determining that they were [indeed] justified, the National Highway Traffic Administration (NHSTA) initiated efforts to develop and implement a symbol more befitting to those in the emergency medical services.

The Star of Life was designed by Leo R. Schwartz, Chief of the Emergency Medical Services Branch of the National Highway Traffic Safety Administration (NHSTA). It was registered as a certified trademark on February 1, 1977 with the Commissioner of Patents and Trademarks in the name of the National Highway Traffic Safety Administration.

At the centre of the Star of Life, are a snake and staff that portray the staff of Asclepius who, according to Greek mythology, was the son of Apollo, the God of Light, Truth, and Prophecy. According to legend, Asclepius learned the art of healing from the centaur Cheron. Fearing that the common man would be rendered immortal with Ascelpius’ knowledge and ability, Zeus, the King of the Gods, killed Asclepius with a bolt of lightning. As time passed, Asclepius was worshipped as a God. People slept in his temples in response to rumors that his spirit effected cures of prescribed remedies to the sick and injured during their dreams.